726
chapter 30
Endocrine Metabolism I: Introduction
28
<D
J C
C l
^
c
8
E JD
ifl?
Extrahypothalam ic
central nervous
system
Endocrine cell 1
Hypothalamus
(neuroendocrine)
Hormone 1
Anterior
Endocrine cell 2
pituitary
Hormone 2
V *
Peripheral
endocrine
Endocrine cell 3
gland
Hormone 3
f i g u r e ; 30-14
Complex feedback regulation of hormone secretion. Hormones of level III endocrine tissues are regulated by a complex
system having both a neuroendocrine reflex component and a simple negative feedback component. Invariably, the
former involves the extrahypothalamic central nervous system (sensory neurons), the hypothalamus (endocrine cell
1
),
and the anterior pituitary (endocrine cell
2
), while the latter involves the anterior pituitary (endocrine cell
2
) and a level
III endocrine tissue (endocrine cell 3). Hormone 3 exerts negative feedback on endocrine cell 2 and hence on its own
secretion. Hormone 3 may also feed back to endocrine cell I and to higher centers, although such cases of feedback may
be positive ones.
Supplemental Readings and References
M. K. Bagchi, M. J. Tsai, B. W. O’Malley, and S. Y. Tsai: Analysis of
the mechanism of steroid hormone receptor-dependent gene activation in
cell-free systems.
Endocrine Reviews
13,
525 (1992).
D. M. Berman and A. G. Gilman: Mammalian RGS proteins: Barbarians at
the gate.
Journal o f Biological C hem istry
273, 1269 (1998).
D. L. Bodenner and R. W. Lash: Thyroid disease mediated by molecular de-
fects in cell surface and nuclear receptors.
A m erican Journal o f M edicine
105,524(1998).
G. A. Brent: The molecular basis of thyroid hormone action.
New E ngland
Journal o f M edicine
331, 847 (1994).
D. L. Cadena and G. N. Gill: Receptor Tyrosine kinases.
FASEB Journal
6
,
2332(1992).
M. A. Carson-Jurica, W. T. Schrader, and B. W. O’Malley: Steroid receptor
family: structure and functions.
Endocrine Reviews
11,201 (1990)
L. De Vries, B. Zheng, T. Fischer, et al.: The regulator of G protein signaling
family.
A nnual Review o f pharm acology and Toxicology
40,
235 (2000).
Z. Farfel, H. R. Bourne, and T. Iiri: The expanding spectrum of G protein
diseases.
N ew E ngland Journal o f M edicine
340,
1012 (1999).
M. E. Freeman, B. Kanyicska, A. Lerant, et al.: Prolactin: structure, function
and regulation of secretion.
Physiological Reviews
80,
1523 (2000).
U. Gether: Uncovering molecular mechanisms involved in activation of G
protein-coupled receptors.
E ndocrine Reviews
21, 90 (2000).
C. K. Glass: Differential Recognition of target genes by nuclear receptor
monomers, dimers and heterodimers.
Endocrine Reviews
15, 391
(1994).
M. A. Lazar: Thyroid hormone receptors: Multiple forms, multiple possi-
bilities.
E ndocrine Reviews
14,
184 (1993).
W. L. Miller: Molecular biology of steroid hormone synthesis.
Endocrine
Reviews 9,
295(1988).
M. Pfahl: Nuclear receptors/AP-1 interactions.
Endocrine Reviews
14, 651
(1993).
J. W. Putney, Jr. and G. S. Bird: The inositol phosphate-calcium signalling
system in nonexcitable cells.
E ndocrine R eviews
14, 610 (1993).
M. D. Ringel, W. F. Schwindinger, and M. A. Levine: Clinical implications of
genetic defects in G proteins: The molecular basis of McCune-Albright
